Kesimpta (Ofatumumab) is a prescription medication designed to address autoimmune conditions, specifically relapsing forms of multiple sclerosis (RMS). Classified as a disease-modifying therapy (DMT), Kesimpta works by targeting CD20-positive B cells, key contributors to the immune response gone awry in multiple sclerosis. By depleting these B cells, Kesimpta helps reduce inflammation and the frequency of relapses associated with RMS.

Here are the primary conditions for which Kesimpta is prescribed:

1. Relapsing Multiple Sclerosis (RMS): Kesimpta is indicated for the treatment of adults with relapsing forms of multiple sclerosis, including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease.
2. Administration: Kesimpta is administered by subcutaneous injection, typically at home. The dosing schedule is established based on your healthcare provider's recommendations.
3. Benefits: The medication aims to decrease the frequency of relapses, slow down the progression of disability, and contribute to an improved quality of life for individuals living with RMS.

As with any medication, Kesimpta may have potential side effects, and its usage requires close monitoring by a healthcare professional. Any concerns or questions regarding Kesimpta or its application for a specific condition should be discussed with your healthcare provider.

Kesimpta (Ofatumumab) is usually administered by subcutaneous injection, and it's crucial to follow your healthcare provider's instructions diligently. Here's a step-by-step guide on how to use Kesimpta:

1. Gather Supplies:
   
   • Kesimpta injection pen or pre-filled syringe
   • Alcohol swabs
   • Sharps disposal container (for used needles and syringes)
   • Clean, well-lit workspace
2. Check Expiration Date: Ensure that the Kesimpta injection pen or pre-filled syringe has not expired. Do not use it if it has.
3. Allow Medication to Reach Room Temperature: Remove the Kesimpta injection pen or pre-filled syringe from the refrigerator and let it sit at room temperature for about 30 minutes before injecting. This can make the injection less painful.
4. Wash Your Hands: Thoroughly wash your hands with soap and water. Dry them with a clean towel.
5. Select an Injection Site:
   
   • Common injection sites include the front of the thighs or the lower abdomen.
   • Rotate injection sites to avoid injecting into the same area repeatedly. Use a different site for each injection.
6. Clean the Injection Site: Using an alcohol swab, clean the selected injection site in a circular motion. Allow the skin to air dry completely.
7. Prepare the Kesimpta Injection Pen or Pre-filled Syringe: If using the Kesimpta injection pen, remove the cap and attach the needle cap. If using a pre-filled syringe, remove the needle cover.
8. Inject the Medication:
   
   • Hold the pen or syringe like a pencil with the hand you write with.
   • Pinch the cleaned area of the skin to create a firm surface for the injection.
   • Insert the needle at a 90-degree angle (perpendicular to the skin).
   • Slowly press the plunger to inject the medication.
   • Continue to press the plunger until it stops moving, and you see the "0" in the dose window.
   • Hold the pen or syringe in place for a few seconds to ensure all the medication is delivered.
9. Dispose of Sharps Safely:
   
   • Place the used needle and syringe or pen in a sharps disposal container. Do not recap the needle.
   • Follow your local regulations for proper disposal of sharps containers.
10. Record the Injection:
    
    • Keep a record of the date, time, and location of your injection. This can help you track your treatment.
11. Store or Discard Unused Medication:
    
    • Store unused Kesimpta in the refrigerator according to the manufacturer's instructions.
    • Do not freeze the medication.
12. Always consult with your healthcare provider or a nurse for thorough training and guidance on how to self-administer Kesimpta. They can provide personalized instructions and address any questions or concerns you may have. Proper preparation and administration are crucial to ensure the effectiveness of the medication and minimise discomfort during the injection.

If you forget to use your prescribed dose of Kesimpta (Ofatumumab), follow these general guidelines to ensure you receive the missed dose as soon as possible:

1. As Soon as You Remember: If you realise that you missed a dose of Kesimpta, take it as soon as you remember. If it's close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.
2. Contact Your Healthcare Provider: It's a good practice to inform your healthcare provider about the missed dose, especially if you frequently miss doses. They can provide guidance on what to do next and whether any adjustments are needed in your treatment plan.
3. Adjust Your Schedule: Depending on when you remember the missed dose, you may need to adjust your dosing schedule to maintain the recommended interval between doses. Your healthcare provider can advise you on how to adjust the timing of your subsequent doses.

Consistency with your dosing schedule is important when taking Kesimpta to effectively manage autoimmune diseases and inflammatory conditions. If you have concerns or questions about missing a dose, it's best to discuss them with your healthcare provider, as they can provide you with personalised guidance based on your specific situation and medical history.

Using too much Kesimpta (Ofatumumab) can potentially lead to an increased risk of side effects and complications. It's crucial to adhere to your healthcare provider's prescribed dosing instructions and not exceed the recommended dosage. If you believe you have accidentally taken more Kesimpta than you should, contact your healthcare provider or seek medical attention immediately.

Overdosing on Kesimpta may result in an increased risk of adverse effects, which can include:

1. Increased Risk of Infections: Kesimpta is an immunosuppressive medication, and using too much can make you more susceptible to infections.
2. Allergic Reactions: An overdose can increase the risk of allergic reactions, which can be severe in some cases. Symptoms may include difficulty breathing, swelling of the face, lips, tongue, or throat, and hives.
3. Exacerbation of Common Side Effects: Overdosing can lead to an exacerbation of common side effects of Kesimpta, such as headache, fatigue, nausea, and injection site reactions.
4. Gastrointestinal Problems: Taking too much Kesimpta may lead to gastrointestinal symptoms like diarrhea, abdominal pain, or upset stomach.

If you believe you have taken an excessive amount of Kesimpta, it's crucial to contact your healthcare provider or go to the nearest healthcare facility immediately. In some cases, they may administer treatments to counteract the effects of the overdose.

To prevent accidental overdoses, always follow your healthcare provider's prescribed dosing instructions and do not self-adjust your dosage. Keep track of your medication schedule and contact your healthcare provider if you have any concerns or questions about your treatment with Kesimpta. Proper and consistent dosing is essential for managing autoimmune diseases and inflammatory conditions effectively.

Kesimpta (Ofatumumab) should be stored properly to maintain its effectiveness and ensure it remains safe for use. Here are guidelines for storing Kesimpta:

1. Refrigeration: Kesimpta should be stored in the refrigerator between 2°C(36°F) to 8°C(46°F). Keep it in its original carton to protect it from light.
2. Avoid Freezing: Do not freeze Kesimpta. Freezing can damage the medication and make it ineffective.
3. Protect from Light: Keep Kesimpta in its original carton to protect it from light. Exposure to light can reduce the medication's stability.
4. Room Temperature Storage (Temporary): If you need to transport Kesimpta or store it at room temperature for a short time, you can keep it at room temperature (up to 25°C) for a single period of up to 14 days. Protect it from light during this time.
5. Do Not Shake: Do not shake Kesimpta. Gently inspect the medication before using it. The solution should be clear and colorless. Do not use it if it's discolored or contains particles.
6. Do Not Use Expired Medication: Check the expiration date on the packaging. Do not use Kesimpta if it has expired.

Always follow the manufacturer's storage instructions provided in the medication package. Proper storage is crucial to maintain the effectiveness of Kesimpta. If you have any doubts or concerns about storing Kesimpta, contact your healthcare provider or pharmacist for guidance.

Kesimpta (Ofatumumab) is a medication used to treat autoimmune conditions, primarily relapsing forms of multiple sclerosis. Like many medications, it can have potential side effects. Not everyone will experience these side effects, and some individuals may experience them to a greater or lesser extent. Common side effects of Kesimpta may include:

1. Upper Respiratory Tract Infections: Symptoms like a runny or stuffy nose, sneezing, and a sore throat are relatively common.
2. Injection Site Reactions: Redness, itching, or pain at the injection site can occur. These symptoms are usually mild and temporary.
3. Nausea: Some individuals may experience mild and temporary nausea.
4. Oral Thrush: Kesimpta may increase the risk of developing oral thrush (a fungal infection in the mouth). Maintaining good oral hygiene can help prevent this side effect.
5. Headache: Mild to moderate headaches can occur.
6. Inflammatory Bowel Disease: In some cases, Kesimpta may increase the risk of inflammatory bowel disease or exacerbate pre-existing conditions.

It's important to note that more serious side effects can also occur, although they are less common. These can include an increased risk of serious infections, such as tuberculosis and fungal infections, as well as the potential for allergic reactions and injection site reactions. Additionally, Kesimpta may have an impact on the immune system, which can increase the risk of certain infections.

As with any medication, the benefits of Kesimpta in treating autoimmune conditions typically outweigh the potential risks of side effects. Your healthcare provider will carefully assess the risks and benefits of Kesimpta for your specific condition and medical history. If you have concerns about side effects or experience any new or worsening symptoms while taking Kesimpta, contact your healthcare provider promptly. They can provide guidance and address your specific needs.

Kesimpta (Ofatumumab) can potentially interact with other medications, and it's essential to inform your healthcare provider about all the medications, supplements, and over-the-counter drugs you are taking to ensure your safety and the effectiveness of your treatment. Here are some important interactions to be aware of:

1. Immunosuppressive Medications: Kesimpta is an immunosuppressive medication, and combining it with other immunosuppressants may increase the risk of infections. Your healthcare provider will carefully assess the risks and benefits if you are taking multiple immunosuppressants.
2. Biologic Drugs: The concurrent use of Kesimpta with other biologic medications may increase the risk of infections and other side effects. Combining multiple biologics is generally not recommended and should only be done under the close supervision of a healthcare provider.
3. Live Vaccines: Kesimpta can weaken your immune system. Avoid receiving live vaccines while on Kesimpta, as they may cause uncontrolled infections. Consult your healthcare provider about vaccination schedules and options.
4. Certain Medications for Multiple Sclerosis: Kesimpta may interact with other medications used to treat multiple sclerosis. Your healthcare provider will consider these interactions when prescribing Kesimpta and may adjust your treatment plan accordingly.

It's important to have a thorough discussion with your healthcare provider about your complete medication list to ensure that Kesimpta can be used safely and effectively in your treatment regimen. Your doctor will consider potential drug interactions, your specific medical condition, and your overall health to make appropriate recommendations. Do not make changes to your medication regimen without consulting with your healthcare provider.

Are Kesimpta Injections Painful?

The experience of pain during Kesimpta (Ofatumumab) injections can vary from person to person. For some individuals, the injections may be relatively painless, while others may experience some discomfort. Factors that can influence the level of pain or discomfort include:

1. Individual Sensitivity: Some people are more sensitive to needle injections and may find the process slightly painful or uncomfortable. Others may hardly feel it.
2. Injection Technique: The way the injection is administered can affect the level of discomfort. Proper technique, such as using a quick, steady motion to insert the needle, can minimize discomfort.
3. Injection Site: The choice of injection site can make a difference. Common injection sites for Kesimpta include the front of the thighs or the lower abdomen. Discuss with your healthcare provider to find the most comfortable site for you.
4. Temperature of Medication: Allowing the Kesimpta Pen or pre-filled syringe to come to room temperature before injection can reduce pain and discomfort.
5. Needle Size: The size of the needle used can influence pain. Smaller-gauge needles tend to be less painful.
6. Relaxation: Staying relaxed and taking slow, deep breaths during the injection can help reduce anxiety and perceived pain.
7. Medication Warm-Up: Some people find it more comfortable to let the skin warm up before injecting, which can be done by holding the pen or syringe in your hand for a few minutes before administering the injection.

It's essential to communicate with your healthcare provider or nurse about any pain or discomfort you experience during Kesimpta injections. They can provide guidance on injection techniques and may offer tips to make the process more comfortable. Additionally, if you find the pain to be a significant issue, your healthcare provider can discuss alternative methods or medications to manage your condition.

Overall, while some discomfort is possible during Kesimpta injections, the benefits of the medication in managing autoimmune diseases and inflammatory conditions typically outweigh the temporary discomfort.

Does Kesimpta Lower Your Immune System?

Yes, Kesimpta (Ofatumumab) is an immunosuppressive medication that works by suppressing or modulating the immune system. It is classified as a monoclonal antibody that targets a specific component of the immune system, B cells. By reducing the activity of B cells, Kesimpta helps control the inflammatory processes involved in autoimmune conditions, primarily relapsing forms of multiple sclerosis.

Because Kesimpta lowers the immune response, it can also increase the risk of infections. It's important to be vigilant for signs of infection while taking Kesimpta and to follow your healthcare provider's instructions and guidelines for monitoring and managing your health. If you develop any symptoms of infection, such as fever, cough, or persistent sore throat, it's important to contact your healthcare provider promptly.

The use of Kesimpta and other immunosuppressive medications should be closely monitored and managed by a healthcare provider to achieve the best balance between controlling the autoimmune disease or inflammatory condition and minimizing the risk of infections and other potential side effects.

How Long Can Kesimpta Be Out of the Fridge?

Kesimpta (Ofatumumab) should be stored in the refrigerator between 2°C to 8°C to maintain its effectiveness and safety. However, there are specific guidelines for how long Kesimpta can be out of the refrigerator under certain circumstances:

1. Travel: If you need to take Kesimpta with you for travel or other reasons, the medication can be stored at room temperature (up to 25°) for a single period of up to 14 days. During this time, it's crucial to protect the medication from direct sunlight and extreme heat.
2. Brief Periods: If Kesimpta is briefly out of the refrigerator for a short time, such as when preparing to administer the injection, it should not pose a problem as long as you return it to the refrigerator promptly.
3. Returning to Refrigerator: Once Kesimpta has been out of the refrigerator at room temperature for any period (up to 14 days for travel), it should be stored back in the refrigerator until the next use.

Always follow the manufacturer's storage instructions provided in the medication package. Proper storage is essential to maintain the effectiveness of Kesimpta. If you have concerns or questions about the storage of Kesimpta, consult with your healthcare provider or pharmacist for guidance.

How Long Does Kesimpta Stay in Your System?

The duration that Kesimpta (Ofatumumab) remains in your system can vary from person to person and may depend on several factors, including your individual metabolism, the specific autoimmune or inflammatory condition being treated, and the frequency of dosing. However, it's important to understand that Kesimpta is typically administered in a way that maintains a consistent level of the medication in your system.

Here are some general guidelines for how long Kesimpta remains active in your body:

1. Regular Dosing: Kesimpta is typically administered on a regular schedule, often every four weeks, to maintain a consistent level of the medication in your system. This helps keep your autoimmune or inflammatory condition under control.
2. Half-Life: The elimination half-life of Kesimpta, or the time it takes for half of the medication to be eliminated from your body, is estimated to be approximately 20 days. This means that it takes several weeks for the medication to be significantly reduced in your system after a dose.
3. Sustained Effect: While the medication's concentration in your bloodstream decreases over time, the therapeutic effect can be sustained well beyond the time it takes for the medication to be eliminated from your body. This is why regular dosing is necessary to maintain disease control.
4. Individual Variation: The duration of action and effectiveness of Kesimpta can vary among individuals. Some people may find that the medication remains effective for the entire dosing interval, while others may experience a decrease in effectiveness toward the end of the dosing cycle.

It's important to follow your healthcare provider's prescribed dosing schedule and to attend regular follow-up appointments. If you have concerns about the duration of action or the effectiveness of Kesimpta, discuss these with your healthcare provider. They can make adjustments to your treatment plan if necessary to ensure you receive the most benefit from the medication.

Ace provides accurate and independent information medically reviewed on prescription medications. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.