Simponi is a brand name for a medication called golimumab. Golimumab is a type of immunosuppressive drug that is used to treat certain autoimmune diseases, particularly conditions that cause inflammation. It belongs to a class of drugs known as tumor necrosis factor (TNF) inhibitors. These medications work by targeting TNF, a protein in the body that plays a role in inflammation.

Simponi (golimumab) is primarily used to treat the following conditions:

1. Rheumatoid Arthritis: It is used to reduce the signs and symptoms of rheumatoid arthritis and to improve physical function in adults with active disease.
2. Ankylosing Spondylitis: Simponi can be used to treat ankylosing spondylitis, a type of arthritis that primarily affects the spine and sacroiliac joints.
3. Psoriatic Arthritis: It is used to manage the symptoms of psoriatic arthritis, a condition that combines joint pain and skin psoriasis.
4. Ulcerative Colitis: In some cases, Simponi may also be prescribed to treat moderate to severe ulcerative colitis, a type of inflammatory bowel disease.

It's important to note that Simponi, like other immunosuppressive medications, can have potential side effects and may increase the risk of infections. It should be used under the supervision of a healthcare professional who can assess the risks and benefits of the treatment for a specific individual and monitor their response to the medication. Always consult with a healthcare provider for more information about Simponi and whether it is an appropriate treatment option for a particular medical condition.

The way you take Simponi (golimumab) can vary depending on the condition you are treating and your healthcare provider's recommendations. Simponi is typically administered as an injection, and there are different dosing schedules for different conditions. It's essential to follow your healthcare provider's instructions carefully. Here's a general guideline for taking Simponi:

1. Administration: Simponi is usually administered by subcutaneous injection, which means it is injected just under the skin. You can either have a healthcare professional administer the injection or, if your healthcare provider has determined it's appropriate, you may be taught to self-administer the injection.
2. Dosing Schedule: The dosing schedule for Simponi can vary based on the condition being treated. Common dosing schedules include:
   
   • Rheumatoid Arthritis and Ankylosing Spondylitis: The typical dosing schedule is one 50 mg injection once a month.
   • Psoriatic Arthritis: The usual dosing schedule is an initial 100 mg injection, followed by 50 mg injections once a month.
   • Ulcerative Colitis: The dosing schedule can vary, and it may include an initial 200 mg injection, followed by 100 mg injections every two weeks or 50 mg injections every four weeks.
3. Injection Sites: Simponi injections are typically given in the thigh or abdomen. Your healthcare provider will provide guidance on the specific injection site. Rotate the injection site with each dose to minimize the risk of irritation or skin reactions.
4. Preparation: If you are self-administering the injection, make sure to follow the instructions provided in the Simponi package insert or by your healthcare provider. The medication is often supplied in pre-filled syringes or pens for ease of use.
5. Storage: Store Simponi as directed in the product's packaging. Usually, it should be kept in the refrigerator. Do not freeze.
6. Monitoring: Your healthcare provider will monitor your response to Simponi and may adjust the dosing schedule as needed.
7. Side Effects: Be aware of potential side effects, and contact your healthcare provider if you experience any unusual or severe side effects.

It's crucial to maintain a close and open line of communication with your healthcare provider throughout your treatment with Simponi. They will provide you with the most accurate and personalised information on how to take the medication, monitor your progress, and address any concerns you may have. This information is intended as a general guideline, and your specific treatment plan may differ based on your medical condition and individual needs.

If you forget to take your scheduled dose of Simponi (golimumab), here are some general steps to follow:

1. Contact Your Healthcare Provider: The first and most important step is to contact your healthcare provider or rheumatologist as soon as possible. They can provide guidance on how to proceed and whether you should take the missed dose or adjust your dosing schedule.
2. Don't Double Dose: It's generally not recommended to take a double dose of Simponi to make up for a missed dose. Taking more than the prescribed amount can increase the risk of side effects and may not be safe.
3. Reschedule the Dose: Your healthcare provider may advise you on when to take the missed dose. They might recommend taking the missed dose as soon as you remember it, or they may adjust your dosing schedule to accommodate the missed dose at the next scheduled injection.
4. Maintain the Usual Schedule: If your healthcare provider advises you to continue with your regular dosing schedule and not take the missed dose, follow their instructions carefully. Missing a single dose may not significantly impact your treatment.
5. Monitor for Symptoms: Pay attention to any changes in your symptoms or any signs of a flare-up of your condition. If you notice worsening symptoms, inform your healthcare provider.
6. Set Reminders: To help prevent missing future doses, consider setting reminders or alarms on your phone or calendar to ensure you adhere to your treatment schedule.

It's essential to have open communication with your healthcare provider throughout your treatment with Simponi. They can provide you with the most appropriate guidance for your specific situation and medical condition. Missing a dose can affect the effectiveness of the medication, so it's important to address the issue promptly and follow your healthcare provider's recommendations.

Taking too much of Simponi (golimumab) can be potentially harmful and may increase the risk of side effects. If you accidentally take an extra dose or believe you have taken more Simponi than prescribed, here's what you should do:

1. Contact Healthcare Provider: Immediately contact your healthcare provider, rheumatologist, or a medical professional to inform them of the situation. They can provide guidance on how to manage the situation and whether any immediate action is required.
2. Monitor for Side Effects: Keep an eye out for any unusual or severe side effects. Common side effects of Simponi can include infections, allergic reactions, and injection site reactions. If you experience any symptoms of side effects, report them to your healthcare provider.
3. Do Not Continue to Overdose: Under no circumstances should you intentionally take additional doses to "balance out" the overdose. This can be dangerous and is not an appropriate response to an accidental overdose.
4. Seek Medical Attention: In some cases of accidental overdose or if you experience severe adverse reactions, you may need to seek medical attention immediately. Your healthcare provider can advise you on the appropriate course of action.

To prevent accidental overdoses, it's crucial to follow your prescribed dosing schedule for Simponi carefully. If you have concerns or questions about your medication, dosing, or potential side effects, consult with your healthcare provider for guidance and clarification. They can help you understand the proper use of the medication and provide instructions specific to your medical condition and treatment plan.

Storing Simponi (golimumab) properly is essential to maintain the medication's effectiveness and safety. Here are the general guidelines for storing Simponi:

1. Refrigeration: Simponi is typically stored in the refrigerator. Keep it at a temperature between 2°C to 8°C. Do not freeze the medication. Avoid exposing it to extreme temperatures.
2. Protect from Light: Keep Simponi in its original packaging or carton to protect it from light. Do not store it in direct sunlight.
3. Prevent Freezing: Ensure that the medication does not freeze. Freezing can damage the medication. Do not use Simponi if it has been frozen.
4. Do Not Shake: Do not shake the medication vigorously. Gently roll or invert the syringe or auto-injector to mix the medication before use, if needed. Shaking can cause the medication to foam, which may affect its efficacy.
5. Keep Out of Reach of Children: Store Simponi out of reach of children and pets to prevent accidental ingestion or tampering.
6. Traveling: If you need to travel with Simponi, use a portable cooler bag with ice packs to keep it within the recommended temperature range. Be cautious when going through security checks at airports, and inform security personnel that you have a medication that requires refrigeration.
7. Check Expiration Date: Always check the expiration date on the medication packaging. Do not use Simponi if it has expired.
8. Discard Properly: Dispose of used syringes or auto-injectors according to local regulations and guidelines for the disposal of medical waste. Do not reuse them.

It's important to follow the storage instructions provided by the manufacturer and your healthcare provider. Proper storage helps ensure that the medication remains effective and safe for use. If you have specific questions or concerns about the storage of Simponi or any aspect of your treatment, consult with your healthcare provider for guidance.

Simponi (golimumab) is a medication that can be effective for treating autoimmune and inflammatory conditions, but like any medication, it may have potential side effects. It's essential to be aware of these side effects and discuss them with your healthcare provider. Common side effects of Simponi can include:

1. Injection Site Reactions: You may experience mild pain, redness, itching, or swelling at the injection site. These reactions are typically temporary and tend to improve over time.
2. Upper Respiratory Tract Infections: Infections of the upper respiratory tract, such as the common cold or sinus infections, are more common in people taking Simponi. These infections are usually mild to moderate in severity.
3. Headache: Some people may experience headaches as a side effect of Simponi.
4. Nausea: Nausea and mild stomach discomfort are possible side effects.
5. Abdominal Pain: Abdominal pain, including discomfort or cramps, can occur in some individuals.
6. Hypertension (High Blood Pressure): Simponi may lead to an increase in blood pressure in some individuals.
7. Dizziness: Feeling lightheaded or dizzy may occur as a side effect.

Less commonly, but more importantly, Simponi can have serious side effects. While these serious side effects are less common, it's crucial to be aware of them and seek medical attention if you experience any of the following:

1. Infections: Simponi can increase the risk of serious infections, including bacterial, fungal, or viral infections. Signs of infection may include fever, chills, cough, and persistent sore throat.
2. Tuberculosis (TB): People taking Simponi may be at higher risk for developing tuberculosis. It's important to be screened for TB before starting Simponi treatment.
3. Hepatitis B Reactivation: In some cases, Simponi can cause reactivation of hepatitis B in individuals who have had previous exposure to the virus.
4. Allergic Reactions: Serious allergic reactions to Simponi are rare but can occur. Seek immediate medical attention if you experience symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing.
5. Heart Failure: Simponi has been associated with an increased risk of heart failure in some individuals.
6. Blood Disorders: Simponi may affect the blood, leading to decreased red blood cell, white blood cell, or platelet counts. This can increase the risk of infections and bleeding.
7. Neurological Disorders: Some individuals may experience neurological symptoms, including demyelinating disorders like multiple sclerosis.

It's important to remember that the benefits of taking Simponi should be weighed against the potential risks and side effects. Your healthcare provider will carefully assess your specific medical condition and health history to determine if Simponi is an appropriate treatment for you. Additionally, they will monitor your condition and any potential side effects during your treatment. If you experience any concerning side effects or have questions, consult your healthcare provider promptly.

Yes, Simponi (golimumab) may interact with other medicines, and it's essential to inform your healthcare provider of all the medications, supplements, and over-the-counter drugs you are taking to ensure your safety and effectiveness of your treatment. Some potential drug interactions to be aware of include:

1. Other Biologic Drugs: Using multiple biologic drugs at the same time may increase the risk of serious infections and should be done with caution. This includes other TNF inhibitors or other biologics used to treat autoimmune diseases.
2. Immunosuppressive Medications: Combining Simponi with other immunosuppressive drugs, such as corticosteroids or methotrexate, may increase the risk of infections. Your healthcare provider will carefully evaluate the benefits and risks of such combinations.
3. Vaccines: Live vaccines should generally be avoided while on Simponi, as they may not be as effective and can pose an infection risk. Before receiving any vaccines, discuss with your healthcare provider.
4. Medications that Affect Liver Function: Some drugs that affect liver function, like certain disease-modifying antirheumatic drugs (DMARDs), may interact with Simponi and affect its clearance from the body.
5. Medications that Affect the Immune System: Medications that suppress or enhance the immune system may interact with Simponi and affect its efficacy.
6. Heart Medications: If you have a history of heart disease or heart failure, your healthcare provider will consider potential interactions with heart medications when prescribing Simponi.
7. CYP450 Enzyme Inhibitors: Some medications that inhibit certain liver enzymes, such as CYP450 enzymes, may interact with Simponi and affect its metabolism in the body.
8. Drugs with Nephrotoxic Potential: Medications that have the potential to cause kidney problems should be used cautiously in conjunction with Simponi.

It's crucial to communicate openly with your healthcare provider about all medications and supplements you are taking, including prescription drugs, over-the-counter medications, and herbal supplements. They can help you understand the potential interactions and make informed decisions about your treatment plan. Your healthcare provider will carefully assess the risks and benefits of any drug combinations and may adjust your treatment plan as needed.

Are Simponi injections painful?

The experience of pain during Simponi (golimumab) injections can vary from person to person. Some individuals may find the injections to be relatively painless, while others may experience mild discomfort or pain. Here are a few factors that can influence the level of pain or discomfort during Simponi injections:

1. Individual Sensitivity: Pain perception varies from person to person. Some individuals are more sensitive to needle pricks and may find injections to be more painful, while others may be less sensitive.
2. Injection Technique: The way the injection is administered can impact the level of discomfort. Proper injection technique, such as using a swift and steady motion, can help minimize pain.
3. Injection Site: The choice of injection site can affect the level of discomfort. Some people may prefer the thigh, while others may prefer the abdomen. Your healthcare provider can help you choose the most comfortable and appropriate injection site for you.
4. Needle Size: The size of the needle used in the Simponi injection can also influence the level of discomfort. Smaller-gauge needles may be less painful for some individuals.
5. Numbing Cream or Ice: Some people use numbing creams or ice packs to help reduce pain at the injection site. Discuss this with your healthcare provider before using such methods.
6. Relaxation Techniques: Being relaxed and calm during the injection may help reduce the perception of pain. Deep breathing or distraction techniques can be helpful.

If you find that Simponi injections are consistently painful or uncomfortable, it's important to discuss this with your healthcare provider. They can provide guidance on injection techniques, needle size, or other strategies to make the process more comfortable. They may also consider alternative treatment options if you have difficulty tolerating the injections. Additionally, if you experience severe or unusual pain, redness, or swelling at the injection site, contact your healthcare provider as this may be a sign of an adverse reaction or infection.

Does Simponi lower your immune system?

Yes, Simponi (golimumab) is an immunosuppressive medication that works by suppressing the immune system. It is classified as a tumor necrosis factor (TNF) inhibitor, and these types of drugs are designed to target and reduce the activity of TNF, a protein that plays a role in the inflammatory response. By inhibiting TNF, Simponi helps to reduce inflammation in conditions like rheumatoid arthritis, ankylosing spondylitis, and other autoimmune diseases.

However, because Simponi suppresses the immune system, it can increase the risk of infections and decrease the body's ability to fight off infections. This is an important consideration when taking Simponi. You should be cautious about exposure to infections and discuss with your healthcare provider any signs of infection, such as fever, chills, or persistent sore throat.

Before starting Simponi treatment, your healthcare provider will evaluate your overall health, including your risk of infections and any history of tuberculosis (TB) exposure. In some cases, TB testing may be necessary before beginning treatment with Simponi.

It's essential to maintain open communication with your healthcare provider while taking Simponi. They can provide guidance on how to minimize infection risks, monitor your health, and adjust your treatment plan if necessary. In some cases, they may recommend certain vaccines before or during treatment to help protect against preventable infections.

How long can Simponi be out of the fridge?

Simponi (golimumab) should be stored in the refrigerator between 2°C to 8°C. However, it's important to know that Simponi can be left out of the refrigerator for a short period of time under certain conditions without significantly affecting its stability. This is important for individuals who need to travel with Simponi or for those who require flexibility in their dosing schedule.

Here are some guidelines for how long Simponi can be out of the refrigerator:

1. Room Temperature Storage: Simponi can be left at room temperature up to 25°C for a single period of up to 7 days. This allows for some flexibility in case you need to travel or if you accidentally take it out of the refrigerator for a short time.
2. Do Not Exceed 7 Days: It's crucial to note that the medication should not be left at room temperature for longer than 7 days. After that time, it should be discarded if not used.
3. Protect from Direct Sunlight: If Simponi is temporarily stored at room temperature, it should be protected from direct sunlight and extreme heat.
4. Do Not Freeze: Avoid freezing Simponi, as freezing can damage the medication.

Always consult the product packaging and the manufacturer's instructions for specific details on how to handle Simponi. If you have concerns about storing or using Simponi outside the recommended temperature range, it's best to discuss your specific situation with your healthcare provider or the manufacturer's customer support for guidance and clarification.

How long does Simponi stay in your system?

The duration that Simponi (golimumab) stays in your system can vary from person to person, but it has an estimated half-life of approximately 11 to 14 days. This means that it takes about 11 to 14 days for half of the drug to be eliminated from your system.

However, it's important to note that the effects of Simponi on your immune system and its therapeutic benefits can last longer than its half-life. The medication's impact on reducing inflammation and symptoms in conditions like rheumatoid arthritis, ankylosing spondylitis, and others may continue even after the drug has reached lower levels in the bloodstream.

The timing of your next dose and the dosing schedule prescribed by your healthcare provider will also influence how long the medication remains active in your system. Simponi is typically administered as a once-monthly injection, and the next dose is often given just before the previous dose's effects wear off.

Your healthcare provider will determine the most appropriate dosing schedule for your specific condition and may make adjustments based on your response to the medication. If you have concerns about the timing and effectiveness of your Simponi treatment, it's important to discuss them with your healthcare provider, who can provide guidance tailored to your individual needs.

How long does Simponi take to work?

The time it takes for Simponi (golimumab) to start working and provide noticeable relief from symptoms can vary from person to person and depends on the specific condition being treated. In general, it may take several weeks to a few months before significant improvement is observed. Here are some factors to consider:

1. Condition and Severity: The time it takes for Simponi to work can depend on the underlying condition and its severity. Some individuals may experience improvement in symptoms more quickly, while others may require more time.
2. Individual Response: Each person's body may respond differently to the medication. Some individuals may notice relief relatively quickly, while others may require more time for the drug to take effect.
3. Dosing Schedule: Simponi is typically administered once a month, and the timing of subsequent doses may impact the speed of symptom relief. Your healthcare provider will determine the most appropriate dosing schedule for your condition.
4. Previous Treatments: Your response to Simponi can also be influenced by prior treatments and whether you have used other medications before starting Simponi.
5. Inflammation and Tissue Damage: It's important to note that while Simponi can help reduce inflammation and alleviate symptoms, it may not reverse tissue damage that has already occurred. Some improvement in joint damage may occur over time as a result of reduced inflammation.
6. Patient Monitoring: Your healthcare provider will monitor your progress while on Simponi, and adjustments to the treatment plan may be made based on your response.

It's essential to maintain open communication with your healthcare provider throughout your treatment with Simponi. If you have concerns about the time it is taking for the medication to work or if you do not notice significant improvement after a reasonable period, discuss your situation with your healthcare provider. They can provide guidance, adjust your treatment plan if necessary, or explore alternative treatments to manage your condition more effectively.

Ace provides accurate and independent information medically reviewed on prescription medications. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.