Taltz is a brand name for the medication ixekizumab. It is a prescription medication used to treat various autoimmune conditions, primarily those involving inflammatory disorders of the skin and joints. Taltz is classified as a biologic drug and specifically as an interleukin-17A (IL-17A) inhibitor.

Conditions that Taltz may be prescribed to treat include:

1. Plaque Psoriasis: Taltz is approved for the treatment of moderate to severe plaque psoriasis in adults.
2. Psoriatic Arthritis: It is used to treat active psoriatic arthritis in adults.
3. Ankylosing Spondylitis: Taltz may also be prescribed for adults with active ankylosing spondylitis.
4. Non-Radiographic Axial Spondyloarthritis: Taltz is approved for the treatment of adults with active non-radiographic axial spondyloarthritis.

Taltz works by targeting and inhibiting the action of IL-17A, a protein involved in the inflammatory process. By blocking IL-17A, Taltz helps to reduce inflammation and alleviate symptoms associated with these conditions. As with any medication, Taltz should be used under the guidance and prescription of a healthcare provider.

Taltz (ixekizumab) is typically administered by subcutaneous injection. It's important to follow your healthcare provider's instructions and receive proper training on how to use it. Here are the general steps for taking Taltz:

1. Gather Supplies:

• Taltz injection pen or pre-filled syringe
• Alcohol swabs
• Sharps disposal container (for used needles and syringes)
• A clean, well-lit workspace

2. Check Expiration Date: Ensure that the Taltz injection pen or pre-filled syringe has not expired. Do not use it if it has.

3. Allow the Medication to Reach Room Temperature: Remove the Taltz injection pen or pre-filled syringe from the refrigerator and let it sit at room temperature for about 30 minutes before injecting. This can make the injection less painful. 

4. Wash Your Hands: Thoroughly wash your hands with soap and water. Dry them with a clean towel.

5. Select an Injection Site:

• Common injection sites include the front of the thighs or the lower abdomen.
• Rotate injection sites to avoid injecting into the same area repeatedly. Use a different site for each injection.

6. Clean the Injection Site: Using an alcohol swab, clean the selected injection site in a circular motion. Allow the skin to air dry completely.

7. Prepare the Taltz Injection Pen or Pre-filled Syringe: If using the Taltz injection pen, remove the cap, and attach the needle cap. If using a pre-filled syringe, remove the needle cover.

8. Inject the Medication:

• Hold the pen or syringe like a pencil with the hand you write with.
• Pinch the cleaned area of the skin to create a firm surface for the injection.
• Insert the needle at a 90-degree angle (perpendicular to the skin).
• Slowly press the plunger to inject the medication.
• Continue to press the plunger until it stops moving, and you see the "0" in the dose window.
• Hold the pen or syringe in place for a few seconds to ensure all the medication is delivered.

9. Dispose of Sharps Safely:

• Place the used needle and syringe or pen in a sharps disposal container. Do not recap the needle.
• Follow your local regulations for proper disposal of sharps containers.

10. Record the Injection: Keep a record of the date, time, and location of your injection. This can help you track your treatment.

11. Store or Discard Unused Medication:

• Store unused Taltz in the refrigerator according to the manufacturer's instructions.
• Do not freeze the medication.

Always consult with your healthcare provider or a nurse for thorough training and guidance on how to self-administer Taltz. They can provide personalized instructions and address any questions or concerns you may have. Proper preparation and administration are crucial to ensure the effectiveness of the medication and minimize discomfort during the injection.

If you forget to take your prescribed dose of Taltz (ixekizumab), follow these general guidelines to ensure you receive the missed dose as soon as possible:

1.  As Soon as You Remember: If you realize that you missed a dose of Taltz, take it as soon as you remember. If it's close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.
2.  Contact Your Healthcare Provider: It's a good practice to inform your healthcare provider about the missed dose, especially if you frequently miss doses. They can provide guidance on what to do next and whether any adjustments are needed in your treatment plan.
3. Adjust Your Schedule: Depending on when you remember the missed dose, you may need to adjust your dosing schedule to maintain the recommended interval between doses. Your healthcare provider can advise you on how to adjust the timing of your subsequent doses.

Consistency with your dosing schedule is important when taking Taltz to effectively manage autoimmune diseases and inflammatory conditions. If you have concerns or questions about missing a dose, it's best to discuss them with your healthcare provider, as they can provide you with personalized guidance based on your specific situation and medical history.

Taking too much Taltz (ixekizumab) can potentially lead to an increased risk of side effects and complications. It's crucial to adhere to your healthcare provider's prescribed dosing instructions and not exceed the recommended dosage. If you believe you have accidentally taken more Taltz than you should, contact your healthcare provider or seek medical attention immediately. Overdosing on Taltz may result in an increased risk of adverse effects, which can include:

1. Increased Risk of Infections: Taltz is an immunosuppressive medication, and taking too much can make you more susceptible to infections.
2.  Allergic Reactions: An overdose can increase the risk of allergic reactions, which can be severe in some cases. Symptoms may include difficulty breathing, swelling of the face, lips, tongue, or throat, and hives.
3. Exacerbation of Common Side Effects: Overdosing can lead to an exacerbation of common side effects of Taltz, such as headache, fatigue, nausea, and injection site reactions.
4. Gastrointestinal Problems: Taking too much Taltz may lead to gastrointestinal symptoms like diarrhea, abdominal pain, or upset stomach.

If you believe you have taken an excessive amount of Taltz, it's crucial to contact your healthcare provider or go to the nearest healthcare facility immediately. In some cases, they may administer treatments to counteract the effects of the overdose. To prevent accidental overdoses, always follow your healthcare provider's prescribed dosing instructions and do not self-adjust your dosage. Keep track of your medication schedule and contact your healthcare provider if you have any concerns or questions about your treatment with Taltz. Proper and consistent dosing is essential for managing autoimmune diseases and inflammatory conditions effectively.

Taltz (ixekizumab) should be stored properly to maintain its effectiveness and ensure it remains safe for use. Here are guidelines for storing Taltz:

1. Refrigeration: Taltz should be stored in the refrigerator between 2°C to 8°C. Keep it in its original carton to protect it from light.
2. Avoid Freezing: Do not freeze Taltz. Freezing can damage the medication and make it ineffective.
3. Protect from Light: Keep Taltz in its original carton to protect it from light. Exposure to light can reduce the medication's stability.
4. Room Temperature Storage (Temporary): If you need to transport Taltz or store it at room temperature for a short time, you can keep it at room temperature (up to25°C) for a single period of up to 14 days. Protect it from light during this time.
5. Do Not Shake: Do not shake Taltz. Gently inspect the medication before using it. The solution should be clear and colourless. Do not use it if it's discoloured or contains particles.
6. Do Not Use Expired Medication: Check the expiration date on the packaging. Do not use Taltz if it has expired.Always follow the manufacturer's storage instructions provided in the medication package. Proper storage is crucial to maintain the effectiveness of Taltz. If you have any doubts or concerns about storing Taltz, contact your healthcare p-rovider or pharmacist for guidance.

Taltz (ixekizumab) is a medication used to treat autoimmune conditions, primarily moderate to severe plaque psoriasis and psoriatic arthritis. Like many medications, it can have potential side effects. Not everyone will experience these side effects, and some individuals may experience them to a greater or lesser extent. Common side effects of Taltz may include:

1. Upper Respiratory Tract Infections: Symptoms like a runny or stuffy nose, sneezing, and a sore throat are relatively common.
2. Injection Site Reactions: Redness, itching, or pain at the injection site can occur. These symptoms are usually mild and temporary.
3. Nausea: Some individuals may experience mild and temporary nausea.
4. Oral Thrush: Taltz may increase the risk of developing oral thrush (a fungal infection in the mouth). Maintaining good oral hygiene can help prevent this side effect.
5. Headache: Mild to moderate headaches can occur.
6. Inflammatory Bowel Disease: In some cases, Taltz may increase the risk of inflammatory bowel disease or exacerbate pre-existing conditions.

It's important to note that more serious side effects can also occur, although they are less common. These can include an increased risk of serious infections, such as tuberculosis and fungal infections, as well as the potential for allergic reactions and injection site reactions. Additionally, Taltz may have an impact on the immune system, which can increase the risk of certain infections. As with any medication, the benefits of Taltz in treating autoimmune conditions typically outweigh the potential risks of side effects. Your healthcare provider will carefully assess the risks and benefits of Taltz for your specific condition and medical history. If you have concerns about side effects or experience any new or worsening symptoms while taking Taltz, contact your healthcare provider promptly. They can provide guidance and address your specific needs.

Taltz (ixekizumab) can potentially interact with other medications, and it's essential to inform your healthcare provider about all the medications, supplements, and over-the-counter drugs you are taking to ensure your safety and the effectiveness of your treatment. Here are some important interactions to be aware of:

1. Immunosuppressive Medications: Taltz is an immunosuppressive medication, and combining it with other immunosuppressants may increase the risk of infections. Your healthcare provider will carefully assess the risks and benefits if you are taking multiple immunosuppressants.
2. Biologic Drugs: The concurrent use of Taltz with other biologic medications may increase the risk of infections and other side effects. Combining multiple biologics is generally not recommended and should only be done under the close supervision of a healthcare provider.
3. Live Vaccines: Taltz can weaken your immune system. Avoid receiving live vaccines while on Taltz, as they may cause uncontrolled infections. Consult your healthcare provider about vaccination schedules and options.
4. Certain Medications for Psoriasis and Autoimmune Diseases: Taltz may interact with other medications used to treat psoriasis and autoimmune conditions. Your healthcare provider will consider these interactions when prescribing Taltz and may adjust your treatment plan accordingly.

It's important to have a thorough discussion with your healthcare provider about your complete medication list to ensure that Taltz can be used safely and effectively in your treatment regimen. Your doctor will consider potential drug interactions, your specific medical condition, and your overall health to make appropriate recommendations. Do not make changes to your medication regimen without consulting with your healthcare provider.

Are Taltz injections painful?

The experience of pain during Taltz (ixekizumab) injections can vary from person to person. For some individuals, the injections may be relatively painless, while others may experience some discomfort. Factors that can influence the level of pain or discomfort include: 

1. Individual Sensitivity: Some people are more sensitive to needle injections and may find the process slightly painful or uncomfortable. Others may hardly feel it. 
2. Injection Technique: The way the injection is administered can affect the level of discomfort. Proper technique, such as using a quick, steady motion to insert the needle, can minimize discomfort 
3. Injection Site: The choice of injection site can make a difference. Common injection sites for Taltz include the front of the thighs or the lower abdomen. Discuss with your healthcare provider to find the most comfortable site for you. 
4. Temperature of Medication: Allowing the Taltz Pen or pre-filled syringe to come to room temperature before injection can reduce pain and discomfort. 
5. Needle Size: The size of the needle used can influence pain. Smaller-gauge needles tend to be less painful. 
6. Relaxation: Staying relaxed and taking slow, deep breaths during the injection can help reduce anxiety and perceived pain.
7. Medication Warm-Up: Some people find it more comfortable to let the skin warm up before injecting, which can be done by holding the pen or syringe in your hand for a few minutes before administering the injection.

It's essential to communicate with your healthcare provider or nurse about any pain or discomfort you experience during Taltz injections. They can provide guidance on injection techniques and may offer tips to make the process more comfortable. Additionally, if you find the pain to be a significant issue, your healthcare provider can discuss alternative methods or medications to manage your condition.

Overall, while some discomfort is possible during Taltz injections, the benefits of the medication in managing autoimmune diseases and inflammatory conditions typically outweigh the temporary discomfort. 

Does Taltz lower your immune system?  

Yes, Taltz (ixekizumab) is an immunosuppressive medication that works by suppressing or modulating the immune system. It is classified as a biologic drug that targets and inhibits the action of a specific protein called interleukin-17A (IL-17A). By blocking IL-17A, Taltz helps reduce inflammation and control the symptoms of autoimmune conditions, primarily moderate to severe plaque psoriasis and psoriatic arthritis.

Because Taltz lowers the immune response, it can also increase the risk of infections. It's important to be vigilant for signs of infection while taking Taltz and to follow your healthcare provider's instructions and guidelines for monitoring and managing your health. If you develop any symptoms of infection, such as fever, cough, or persistent sore throat, it's important to contact your healthcare provider promptly. 

The use of Taltz and other immunosuppressive medications should be closely monitored and managed by a healthcare provider to achieve the best balance between controlling the autoimmune disease or inflammatory condition and minimizing the risk of infections and other potential side effects. 

How long can Taltz be out of the fridge?  

Taltz (ixekizumab) should be stored in the refrigerator between 2°C(36°F) to 8°C(46°F) to maintain its effectiveness and safety. However, there are specific guidelines for how long Taltz can be out of the refrigerator under certain circumstances:

1. Travel: If you need to take Taltz with you for travel or other reasons, the medication can be stored at room temperature (up to 25°C(77°F)) for a single period of up to 14 days. During this time, it's crucial to protect the medication from direct sunlight and extreme heat. 
2. Brief Periods: If Taltz is briefly out of the refrigerator for a short time, such as when preparing to administer the injection, it should not pose a problem as long as you return it to the refrigerator promptly. 
3. Returning to Refrigerator: Once Taltz has been out of the refrigerator at room temperature for any period (up to 14 days for travel), it should be stored back in the refrigerator until the next use. 

Always follow the manufacturer's storage instructions provided in the medication package. Proper storage is essential to maintain the effectiveness of Taltz. If you have concerns or questions about the storage of Taltz, consult with your healthcare provider or pharmacist for guidance. 

How long does Taltz stay in your system?

The duration that Taltz (ixekizumab) remains in your system can vary from person to person and may depend on several factors, including your individual metabolism, the specific autoimmune or inflammatory condition being treated, and the frequency of dosing. However, it's important to understand that Taltz is typically administered in a way that maintains a consistent level of the medication in your system.

Here are some general guidelines for how long Taltz remains active in your body: 

1. Regular Dosing: Taltz is typically administered on a regular schedule, often every one to two weeks, to maintain a consistent level of the medication in your system. This helps keep your autoimmune or inflammatory condition under control.
2. Half-Life: The elimination half-life of Taltz, or the time it takes for half of the medication to be eliminated from your body, is estimated to be approximately three weeks. This means that it takes several weeks for the medication to be significantly reduced in your system after a dose. 
3. Sustained Effect: While the medication's concentration in your bloodstream decreases over time, the therapeutic effect can be sustained well beyond the time it takes for the medication to be eliminated from your body. This is why regular dosing is necessary to maintain disease control. 
4. Individual Variation: The duration of action and effectiveness of Taltz can vary among individuals. Some people may find that the medication remains effective for the entire dosing interval, while others may experience a decrease in effectiveness toward the end of the dosing cycle. 

It's important to follow your healthcare provider's prescribed dosing schedule and to attend regular follow-up appointments. If you have concerns about the duration of action or the effectiveness of Taltz, discuss these with your healthcare provider. They can make adjustments to your treatment plan if necessary to ensure you receive the most benefit from the medication.

How long does Taltz take to work?

The time it takes for Taltz (ixekizumab) to start working can vary from person to person and depends on the specific condition being treated. In many cases, patients may start to notice an improvement in their symptoms within a few weeks to a few months of starting Taltz treatment. However, it's essential to keep in mind the following factors that can influence how long it takes for Taltz to be effective: 

1. Condition Being Treated: The response time to Taltz can vary depending on the autoimmune or inflammatory condition being treated. Some individuals may experience relief from their symptoms relatively quickly, while others may require more time for the medication to take full effect. 
2. Dosing Frequency: The dosing schedule prescribed by your healthcare provider can also impact how quickly you experience the effects of Taltz. In some cases, an initial loading dose may be given to help achieve a faster response. 
3. Individual Variation: Each person's body may respond differently to the medication. Some individuals may notice a significant improvement in a matter of weeks, while others may require a few months to achieve optimal results. 
4. Severity of the Condition: The severity of your autoimmune or inflammatory condition can affect how long it takes for Taltz to work. Those with more severe symptoms may take longer to experience relief. 

It's crucial to follow your healthcare provider's prescribed dosing schedule and continue taking Taltz as directed, even if you don't notice immediate improvement. It may take time for the medication to fully control your condition, so be patient and communicate regularly with your healthcare provider to track your progress. 

If you have concerns about the time it's taking for Taltz to work or if you're experiencing side effects or a lack of improvement, discuss these with your healthcare provider. They can adjust your treatment plan or explore other options to better manage your condition.

Ace provides accurate and independent information medically reviewed on prescription medications. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.