Tremfya is a brand name for the medication guselkumab. It is a prescription medication used to treat certain autoimmune conditions, specifically moderate to severe plaque psoriasis in adults.

Tremfya belongs to a class of drugs known as interleukin-23 (IL-23) inhibitors. It works by targeting and blocking the action of IL-23, a cytokine involved in the inflammatory process. By inhibiting IL-23, Tremfya helps to reduce inflammation and alleviate symptoms associated with plaque psoriasis.

The medication is typically administered as a subcutaneous injection. The dosing regimen may involve initial loading doses followed by maintenance doses.

As with any medication, it's important to use Tremfya under the guidance and prescription of a healthcare provider. Individuals considering or using Tremfya should discuss potential side effects, benefits, and risks with their healthcare provider before starting or continuing treatment. Regular follow-up appointments and monitoring are typically part of the treatment plan to ensure its effectiveness and manage any potential side effects.

Tremfya (guselkumab) is typically administered as a subcutaneous injection. It's important to follow the prescribed dosage and administration schedule provided by your healthcare provider. Here are general guidelines on how to inject Tremfya:

1. Gather Supplies:

• Tremfya prefilled syringe or autoinjector
• Alcohol swabs
• Sharps disposal container
• Clean, well-lit workspace

2. Check Expiration Date: Ensure Tremfya has not expired before use.

3. Allow Medication to Reach Room Temperature: Remove from the refrigerator and let it sit for about 30 minutes before injecting.

4. Wash Your Hands: Thoroughly wash hands with soap and water.

5. Select an Injection Site: Common sites include thighs or lower abdomen, rotating to avoid repeated injection in the same area.

6. Clean the Injection Site: Use an alcohol swab to clean the selected site.

7. Prepare the Tremfya Injection: Remove the cap and, if applicable, attach the needle cap.

8. Inject the Medication:

• Hold the syringe like a pencil, insert the needle at a 90-degree angle, and press the plunger until "0" is visible.
• Hold in place for a few seconds to ensure complete delivery.

9. Dispose of Sharps Safely: Place used needle and syringe in a sharps container.

10. Record the Injection: Maintain a record of the date, time, and location for tracking purposes.

11. Store or Discard Unused Medication: Follow manufacturer's instructions for storage.

It's crucial to consult healthcare providers or nurses for comprehensive training and guidance on self-administering Tremfya.

If you forget to take a scheduled dose of Tremfya, it's important to take the missed dose as soon as you remember. However, if it is close to the time for your next scheduled dose, it's generally recommended not to take a double dose to make up for the missed one.

Here are some general guidelines if you forget to take Tremfya:

1. Take the Missed Dose: As soon as you remember that you missed a dose, take it.
2. Resume Regular Schedule: After taking the missed dose, resume your regular dosing schedule as prescribed by your healthcare provider.
3. Inform Your Healthcare Provider: It's advisable to inform your healthcare provider about the missed dose during your next follow-up appointment. They can provide specific guidance based on your individual treatment plan.
4. Do Not Double Dose: Avoid taking a double dose to make up for the missed one, especially if it's close to the time for your next scheduled dose. Taking more than the prescribed amount can increase the risk of side effects without providing additional benefits.

Consistency in following your prescribed dosing schedule is important for the effectiveness of Tremfya in managing your condition. If you have concerns about missed doses or need guidance on how to handle a missed dose, it's always best to reach out to your healthcare provider. They can provide personalised advice based on your specific situation and medical history.

If you accidentally take too much Tremfya (guselkumab), it's important to seek medical attention immediately. Taking more than the prescribed dose can increase the risk of side effects without providing additional benefits. Here are steps to take if you suspect an overdose:

1. Contact Emergency Services: If you experience symptoms of overdose or if you have taken more Tremfya than prescribed, call emergency services or go to the nearest emergency room.
2. Inform Healthcare Provider: Notify your healthcare provider as soon as possible about the overdose. They can provide guidance on the appropriate steps to take and may adjust your treatment plan accordingly.
3. Monitor for Symptoms: Be aware of any unusual or severe symptoms that may indicate an overdose. These symptoms can vary, so it's important to seek medical attention even if you are unsure.
4. Do Not Double Dose: To avoid accidental overdose in the future, do not take a double dose to make up for a missed one. Stick to your prescribed dosing schedule as directed by your healthcare provider.

Taking too much Tremfya can increase the risk of side effects, which may include an increased susceptibility to infections or other adverse reactions. It's crucial to follow your healthcare provider's instructions carefully and to communicate any concerns or incidents of accidental overdose promptly.

Always consult with your healthcare provider for personalised advice based on your specific situation. They can provide guidance on managing any potential side effects or complications associated with an overdose and adjust your treatment plan as needed.

The storage of Tremfya (guselkumab) is crucial to ensure the medication's effectiveness and stability. Here are general guidelines on how to store Tremfya:

1. Refrigeration: Tremfya should be stored in the refrigerator at a temperature between 2°C to 8°C. Keep the medication in its original carton to protect it from light.
2. Do Not Freeze: Do not freeze Tremfya. Freezing can damage the medication and affect its efficacy.
3. Protection from Light: Store Tremfya in its original carton to protect it from light. Exposure to light can also affect the stability of the medication.
4. Keep in Original Packaging: Do not remove Tremfya from its original packaging until you are ready to use it. This helps protect the medication from environmental factors.
5. Short-Term Room Temperature Storage: In some cases, Tremfya may be kept at room temperature (up to 25°C) for a short period (up to 30 days). However, once taken out of the refrigerator, it should not be returned.

Always follow the specific storage instructions provided by the manufacturer and your healthcare provider. If you have any questions or concerns about the storage of Tremfya, consult with your healthcare provider or pharmacist for guidance. Never use Tremfya that has been frozen or exposed to temperatures outside the recommended range without consulting your healthcare provider.

Tremfya (guselkumab) is a medication that may cause side effects. It's important to note that not everyone will experience these side effects, and some individuals may experience side effects to varying degrees. Common and serious side effects of Tremfya may include:

Common Side Effects:

1. Upper Respiratory Tract Infections: Symptoms such as a runny or stuffy nose, sore throat, or sinus congestion.
2. Headache: Mild to moderate headaches.
3. Injection Site Reactions: Redness, swelling, or itching at the injection site.

Serious Side Effects:

1. Infections: Tremfya can increase the risk of infections, including upper respiratory infections and fungal infections. It's important to monitor for signs of infection, such as fever, chills, or persistent cough.
2. Gastrointestinal Perforations: In rare cases, Tremfya may increase the risk of gastrointestinal perforations, which are a serious condition.
3. Liver Problems: Elevated liver enzymes have been reported in some individuals taking Tremfya.
4. Hypersensitivity Reactions: Severe allergic reactions, including anaphylaxis, have been reported.

It's crucial to seek medical attention if you experience any severe or persistent side effects. Additionally, inform your healthcare provider about any new or unusual symptoms you may be experiencing.

Before starting Tremfya, discuss your medical history and any pre-existing conditions with your healthcare provider. They can provide more personalized information about the potential side effects based on your individual health profile.

This is not an exhaustive list of side effects, and individuals may experience other effects. Always consult with your healthcare provider or pharmacist for comprehensive information about the potential side effects of Tremfya and what to do if you experience them.

Tremfya can interact with several types of drugs, including:

• antidepressants
• antipsychotics
• opioids

This list does not contain all the types of drugs that may interact with Tremfya. Your doctor or pharmacist can tell you more about these interactions and any others that may occur.

Other interactions

It’s recommended that you don’t receive live vaccines while using Tremfya. Live vaccines are made from small amounts of a live virus. This is unlike inactivated vaccines, which contain a dead or inactive form of a virus.

Normally, getting a live vaccine won’t cause an infection if your immune system is healthy. But Tremfya can lower the ability of your immune system to fight off infections. So the risk of getting an infection from a live vaccine is higher when you’re taking Tremfya.

Be sure to talk with your doctor or pharmacist before getting any vaccines while you’re using Tremfya.

Are Tremfya Injections Painful?

The experience of pain during injections, including Tremfya (guselkumab) injections, can vary from person to person. Pain perception is subjective and influenced by individual factors such as pain tolerance, anxiety, and the specific injection technique used.

Tremfya is typically administered as a subcutaneous injection, meaning it is injected under the skin. Some people may experience mild discomfort or a sensation of pressure during the injection, while others may find it relatively painless. The needle used for subcutaneous injections is smaller than those used for intramuscular injections, which may contribute to a more comfortable experience.

To potentially reduce pain or discomfort during Tremfya injections:

1. Room Temperature Injection: Allowing the medication to reach room temperature before the injection can sometimes minimize discomfort.

2. Relaxation Techniques: Practicing relaxation techniques, such as deep breathing, before and during the injection may help reduce anxiety and discomfort.

3. Proper Technique: Ensure that the injection is administered using the proper technique, as instructed by your healthcare provider or a trained healthcare professional.

If you have concerns about pain during Tremfya injections or if you experience significant discomfort, it's important to communicate with your healthcare provider. They can offer guidance on techniques to minimize pain or explore alternative injection methods if necessary. Additionally, they can address any concerns you may have about the injection process.

Does Tremfya Lower Your Immune System?

Yes, Tremfya (guselkumab) belongs to a class of medications known as biologics, specifically interleukin-23 (IL-23) inhibitors. These medications are designed to modulate the immune system's activity, and as a result, they can impact immune responses.

Tremfya works by targeting and inhibiting IL-23, a cytokine involved in the inflammatory process. By blocking IL-23, Tremfya helps reduce inflammation and alleviate symptoms associated with certain autoimmune conditions, such as psoriasis.

However, because Tremfya has an immunosuppressive effect, it can potentially affect the body's ability to mount a normal immune response to infections. This means individuals taking Tremfya may have an increased susceptibility to infections. Before starting Tremfya or any immunosuppressive medication, healthcare providers typically assess the patient's medical history, including any history of infections, to ensure the appropriate use of the medication.

It's crucial for individuals using Tremfya to follow their healthcare provider's instructions, report any signs of infection promptly, and receive recommended vaccinations, excluding live vaccines, before starting treatment. As with any immunosuppressive medication, individuals on Tremfya should communicate regularly with their healthcare provider and seek medical attention if they develop signs of infection.

Individuals considering Tremfya or currently using it should discuss the potential benefits and risks, including the impact on the immune system, with their healthcare provider.

How Long Can Tremfya Be Out of the Fridge?

The storage requirements for Tremfya (guselkumab) typically involve refrigeration to maintain the stability of the medication. It's important to follow the specific storage instructions provided by the manufacturer and your healthcare provider. The general guidance for most medications, including biologics like Tremfya, is to avoid leaving them out of the fridge for an extended period.

If you accidentally leave Tremfya out of the refrigerator, it's important to adhere to the following guidelines:

1. Return to Refrigeration Promptly: If Tremfya has been left out at room temperature, return it to the refrigerator as soon as possible.

2. Limited Room Temperature Storage: Some medications can be left at room temperature for a short period. Check the product information or consult with your healthcare provider to see if Tremfya allows for limited room temperature storage. If it does, follow the recommended time limit.

3. Do Not Freeze: Avoid freezing Tremfya. If it has been frozen, do not use it, and consult with your healthcare provider.

4. Inspect for Changes: Before using Tremfya, visually inspect the solution for any changes in color, clarity, or the presence of particles. Do not use the medication if it appears altered.

Always consult with your healthcare provider or pharmacist for specific instructions regarding the storage of Tremfya. If you have concerns about the storage conditions or if Tremfya has been left out for an extended period, contact your healthcare provider for guidance on whether it is still safe to use and how to proceed.

How Long Does Tremfya Take to Work?

The time it takes for Tremfya (guselkumab) to show noticeable effects can vary among individuals and depends on the specific condition being treated. In clinical trials for psoriasis, which is one of the conditions for which Tremfya is approved, some patients reported improvement in their symptoms within the first few weeks of treatment, while others may take longer to experience the full benefits.

It's important to understand that the response to Tremfya can be gradual, and individual responses may vary. Factors influencing the time it takes for Tremfya to work include the severity of the condition, the specific autoimmune or inflammatory disease being treated, and the individual's unique physiology.

Patients are typically advised to follow their prescribed treatment plan and continue with regular follow-up appointments with their healthcare provider. During these follow-ups, healthcare providers can assess the progress of treatment and make any necessary adjustments.

If you have specific concerns about the timing of Tremfya's effectiveness or if you are not experiencing the desired results, it's crucial to communicate openly with your healthcare provider. They can provide guidance based on your individual response to the medication and may adjust the treatment plan accordingly.

How Long Does Tremfya Take to Work?

The time it takes for Tremfya (guselkumab) to show noticeable effects can vary among individuals and depends on the specific condition being treated. In clinical trials for psoriasis, which is one of the conditions for which Tremfya is approved, some patients reported improvement in their symptoms within the first few weeks of treatment, while others may take longer to experience the full benefits.

It's important to understand that the response to Tremfya can be gradual, and individual responses may vary. Factors influencing the time it takes for Tremfya to work include the severity of the condition, the specific autoimmune or inflammatory disease being treated, and the individual's unique physiology.

Patients are typically advised to follow their prescribed treatment plan and continue with regular follow-up appointments with their healthcare provider. During these follow-ups, healthcare providers can assess the progress of treatment and make any necessary adjustments.

If you have specific concerns about the timing of Tremfya's effectiveness or if you are not experiencing the desired results, it's crucial to communicate openly with your healthcare provider. They can provide guidance based on your individual response to the medication and may adjust the treatment plan accordingly.

Ace provides accurate and independent information medically reviewed on prescription medications. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.