CRINONE® is used to supplement or replace natural progesterone in women undergoing Assisted Reproductive Technology (ART) procedures, such as in vitro fertilisation (IVF). Progesterone is essential for preparing the uterine lining to receive and support a fertilised egg.

CRINONE® is prescribed for luteal phase support, ensuring the uterus is ready for implantation and early pregnancy development.

It may also be used to treat progesterone deficiency in women with secondary amenorrhea.

The typical dosage for luteal phase support is one application of CRINONE® 8% gel inserted vaginally once daily, starting after egg retrieval and continuing until pregnancy is confirmed. In some cases, your doctor may recommend twice-daily administration.

Always follow your fertility specialist’s instructions regarding dosage and duration.

If you forget to use CRINONE®, administer the missed dose as soon as you remember, unless it is close to the time of your next scheduled dose. In that case, skip the missed dose and continue with your regular schedule.

Do not use a double dose to make up for the missed one. Contact your doctor if you are unsure.

In case of accidental overdose, contact your doctor or the Poisons Information Centre (Australia: 13 11 26) for advice.

Symptoms of overdose may include dizziness, nausea, or abdominal discomfort.

Store CRINONE® below 25°C in its original packaging to protect it from light and moisture. Do not freeze the applicators.

Keep the medication out of reach of children and dispose of used applicators safely.

Common side effects include mild vaginal irritation, discharge, or itching. Some women may experience bloating, headaches, dizziness, or breast tenderness.

Rare but serious side effects include allergic reactions, such as swelling of the face or throat, difficulty breathing, or severe abdominal pain. Contact your doctor immediately if you experience severe symptoms.

Other side effects, such as spotting or cramping, may occur during ART procedures and are typically unrelated to CRINONE®.

CRINONE® may interact with other vaginal medications or treatments.

Inform your doctor about all medications, supplements, or herbal products you are using to avoid potential interactions.

Your fertility specialist will guide you on how to safely incorporate CRINONE® into your treatment plan.

How does CRINONE® work in fertility treatments? CRINONE® delivers progesterone directly to the uterus, helping to prepare the uterine lining for implantation and supporting early pregnancy. Its bioadhesive gel formulation ensures sustained release and targeted delivery, minimising systemic side effects.

Can I administer CRINONE® myself? Yes, CRINONE® is designed for self-administration. The pre-filled applicators make it easy to insert the gel vaginally. Your doctor or nurse will provide instructions to ensure proper technique.

What should I do if I experience side effects? Mild side effects, such as vaginal irritation or discharge, are common and usually temporary. If you experience severe symptoms, such as difficulty breathing or abdominal pain, contact your doctor immediately. Your healthcare team is here to support you.

Can CRINONE® be used during pregnancy? CRINONE® is often continued during early pregnancy to support the uterine lining. Your doctor will advise you on how long to use CRINONE® based on your individual needs.

How should I store CRINONE®? Store CRINONE® below 25°C in its original packaging, away from light and moisture. Do not freeze the applicators, and ensure they are kept out of reach of children.

Ace provides accurate and independent information medically reviewed on prescription medications. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.