GONAL-f® is a recombinant follicle-stimulating hormone (FSH) used in Assisted Reproductive Technology (ART) treatments, such as in vitro fertilisation (IVF). It stimulates the ovaries to develop multiple follicles, increasing the number of eggs available for retrieval.

GONAL-f® is also used to treat anovulatory infertility in women who have not responded to clomiphene citrate.

In men, it may be prescribed alongside human chorionic gonadotropin (hCG) to stimulate sperm production.

The dosage of GONAL-f® is individualised based on the patient’s response to treatment. For ovarian stimulation, the typical starting dose is 75–150 IU per day, administered as a subcutaneous injection.

The dose may be adjusted by your fertility specialist depending on your ovarian response, as monitored through blood tests and ultrasounds.

Treatment usually begins within the first 7 days of the menstrual cycle and continues until the desired follicular development is achieved.

If you forget to take a dose, contact your fertility clinic or doctor immediately for advice.

Do not administer a double dose to make up for the missed one.

Timing is critical in fertility treatments, so follow your doctor’s instructions closely.

In case of an overdose, seek immediate medical attention. Symptoms may include abdominal discomfort, bloating, or signs of ovarian hyperstimulation.

Contact the Poisons Information Centre (Australia: 13 11 26) or your doctor for guidance.

Store GONAL-f® in a refrigerator at 2°C to 8°C. Do not freeze the medication. If refrigeration is unavailable, GONAL-f® can be stored below 25°C for a single period of up to three months.

After first use, the pen may be stored below 25°C for up to 28 days.

Keep the medication in its original packaging to protect it from light and moisture, and ensure it is out of reach of children.

Common side effects include mild redness, swelling, or itching at the injection site, which usually resolves quickly. Other possible side effects include headaches, nausea, fatigue, or abdominal discomfort.

Rare but serious side effects include symptoms of Ovarian Hyperstimulation Syndrome (OHSS), such as severe pelvic pain, nausea, vomiting, or sudden weight gain.

Contact your doctor immediately if you experience severe symptoms.

GONAL-f® may interact with other hormonal medications used during fertility treatments.

Inform your doctor about all medications, supplements, or herbal products you are taking to avoid potential interactions.

Your fertility specialist will guide you on how to safely incorporate GONAL-f® into your treatment plan.

How does GONAL-f® work in fertility treatments? GONAL-f® contains follitropin alfa, a recombinant form of follicle-stimulating hormone (FSH). It stimulates the ovaries to develop multiple follicles, increasing the number of eggs available for retrieval during IVF. This enhances the chances of successful fertilisation and implantation.

Can I administer GONAL-f® myself? Yes, GONAL-f® is designed for self-administration. The pre-filled pen makes it easy to inject the medication subcutaneously. Your doctor or nurse will provide instructions to ensure proper technique.

What should I do if I experience side effects? Mild side effects, such as redness or swelling at the injection site, are common and usually temporary. If you experience severe symptoms, such as signs of OHSS, contact your doctor immediately. Your healthcare team is here to support you.

Can GONAL-f® be used during pregnancy? No, GONAL-f® must not be used during pregnancy. It is specifically designed for use during ovarian stimulation cycles before conception. If you suspect you may be pregnant, inform your doctor immediately.

How should I store GONAL-f®? Store GONAL-f® in a refrigerator at 2°C to 8°C. If refrigeration is unavailable, it can be stored below 25°C for up to three months. After first use, the pen may be stored below 25°C for up to 28 days. Always keep the medication in its original packaging to protect it from light and moisture.

Ace provides accurate and independent information medically reviewed on prescription medications. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.