Inlyta (axitinib) is a targeted cancer medicine used to treat advanced renal cell carcinoma (RCC), the most common type of kidney cancer. It belongs to a class called tyrosine kinase inhibitors (TKIs) that block VEGF receptors, proteins that cancer cells use to grow new blood vessels to feed tumour growth.

Take Inlyta tablets by mouth twice daily, approximately 12 hours apart. It can be taken with or without food.

Swallow tablets whole with a glass of water. Do not crush or split them.

Blood pressure must be well controlled before and during treatment. Measure your blood pressure at home regularly as directed.

If you miss a dose and your next dose is due in less than 6 hours, skip the missed dose. Otherwise, take it as soon as you remember and then resume your regular schedule. Never take two doses at once.

Contact your oncologist or emergency services immediately.

• Store below 25°C
• Keep in the original packaging
• Keep out of reach of children

Very common side effects:

• High blood pressure (hypertension): very common and often requires medication to control it
• Fatigue
• Diarrhoea
• Nausea and vomiting
• Decreased appetite
• Hand-foot syndrome: redness, pain, blistering, or thickening of the skin on the palms and soles

Serious side effects:

• Hypertensive crisis: seek emergency help immediately if you have a severe headache, visual disturbance, or confusion
• Arterial thrombosis (blood clots in arteries): chest pain, arm or leg pain, or sudden weakness may indicate a clot
• Thyroid problems: thyroid function will be monitored
• Wound healing problems: Inlyta should be stopped before planned surgery

Blood tests, blood pressure monitoring, and thyroid checks are part of routine follow-up.

• Strong CYP3A4 inhibitors (ketoconazole, clarithromycin, grapefruit juice): increase axitinib levels
• Strong CYP3A4 inducers (rifampicin, carbamazepine, St John's Wort): significantly reduce axitinib levels

Tell your oncologist and pharmacist about all medicines and supplements.

Why is my blood pressure so important with Inlyta?

Axitinib blocks VEGF pathways that also regulate normal blood vessel tone. This causes blood pressure to rise in most patients. Paradoxically, some studies suggest that a certain degree of blood pressure elevation may be a sign the medicine is working. Your doctor will use blood pressure medicines to keep it in a safe range rather than reducing the Inlyta dose prematurely.

What is hand-foot syndrome and how do I manage it?

Hand-foot syndrome causes redness, pain, and in some cases blistering or peeling on the palms and soles. Moisturise your hands and feet regularly, wear comfortable cushioned shoes, and avoid prolonged pressure on these areas. Tell your doctor about any changes to your skin as dose adjustments may help.

Ace provides accurate and independent information medically reviewed on prescription medications. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.