ARX-LETROZOLE® is commonly used in fertility treatments to induce ovulation in women with ovulatory disorders, such as polycystic ovary syndrome (PCOS). It works by reducing estrogen levels in the body, which stimulates the release of follicle-stimulating hormone (FSH) and luteinising hormone (LH). This promotes the growth and release of a mature egg, increasing the chances of conception.

It is also used off-label in controlled ovarian stimulation protocols for Assisted Reproductive Technology (ART) cycles, such as in vitro fertilisation (IVF).

The typical dosage for ovulation induction is 2.5 mg to 7.5 mg taken orally once daily for five consecutive days, starting on the third, fourth, or fifth day of the menstrual cycle.

Your fertility specialist will determine the exact dosage and timing based on your individual treatment plan.

Always follow your doctor’s instructions carefully.

If you forget to take a dose, take it as soon as you remember. However, if it is close to the time of your next scheduled dose, skip the missed dose and continue with your regular schedule.

Do not take a double dose to make up for the missed one. Contact your doctor or pharmacist if you are unsure.

In case of an overdose, seek immediate medical attention. Symptoms of overdose may include dizziness, nausea, vomiting, or severe fatigue. Contact the Poisons Information Centre (Australia: 13 11 26) or your doctor or pharmacist for advice.

Store ARX-LETROZOLE® below 25°C in its original packaging to protect it from moisture and light.

Keep it out of reach of children.

Do not use the medication after the expiry date printed on the packaging.

Common side effects include hot flushes, headaches, dizziness, fatigue, and nausea. Some women may experience joint or muscle pain, increased sweating, or mild swelling.

Rare but serious side effects include blurred vision, chest pain, or signs of an allergic reaction, such as swelling of the face, lips, or throat, and difficulty breathing.

Contact your doctor immediately if you experience any severe or unusual symptoms.

Letrozole may interact with medications such as tamoxifen, estrogen-containing drugs, or certain supplements.

Inform your doctor about all medications, vitamins, or herbal products you are taking to avoid potential interactions.

Avoid alcohol while taking ARX-LETROZOLE®, as it may exacerbate side effects like dizziness or fatigue

Can ARX-LETROZOLE® be used during pregnancy? ARX-LETROZOLE® is not intended for use during pregnancy, as its role is specifically to support ovulation before conception. Once pregnancy is confirmed, this medication is no longer needed and could potentially affect the developing baby. If you suspect you may be pregnant while using ARX-LETROZOLE®, contact your doctor immediately for advice.

How does ARX-LETROZOLE® help with fertility? ARX-LETROZOLE® works by temporarily lowering estrogen levels in the body. This stimulates the pituitary gland to release hormones that encourage the ovaries to produce and release mature eggs. For women with ovulation challenges, such as those caused by polycystic ovary syndrome (PCOS), ARX-LETROZOLE® can be an effective part of a treatment plan.

How long does it take for ARX-LETROZOLE® to stimulate ovulation? For most women, ovulation occurs within 5 to 10 days after completing the 5-day course of ARX-LETROZOLE®. Your fertility specialist may use blood tests or ultrasounds to monitor your response and timing during treatment.

Can I use ARX-LETROZOLE® while breastfeeding? ARX-LETROZOLE® is not recommended for breastfeeding women because it may pass into breast milk and potentially affect the baby. If you are breastfeeding and considering fertility treatments, consult your doctor for alternative options.

What should I do if I experience side effects? If you experience mild side effects such as headaches or nausea, these are often temporary and manageable. However, your comfort is important, so let your doctor know about any symptoms during your next visit. If you notice unusual or severe symptoms, such as chest pain or difficulty breathing, seek medical attention promptly. Your healthcare team is here to support you.

Can I drink alcohol while taking ARX-LETROZOLE®? It is best to avoid alcohol while using ARX-LETROZOLE®, as it can intensify certain side effects like dizziness or fatigue. Staying hydrated and maintaining a healthy lifestyle during treatment will help your body respond effectively.

What should I do if I miss a dose? If you forget to take a dose, take it as soon as you remember, unless it is close to the time of your next scheduled dose. In that case, skip the missed dose and continue with your regular schedule. Do not take a double dose to compensate for the missed one. If you’re unsure, your fertility clinic is just a call away to provide guidance.

Ace provides accurate and independent information medically reviewed on prescription medications. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.