Ozurdex is a tiny slow-release implant containing dexamethasone (a corticosteroid) that is placed directly inside the eye by a specialist eye doctor. It gradually releases dexamethasone over several months to reduce inflammation inside the eye.

Ozurdex is used to treat:

• Macular oedema following retinal vein occlusion (RVO)
• Non-infectious posterior uveitis (inflammation inside the eye)
• Diabetic macular oedema (DME)

The implant is biodegradable, meaning it slowly dissolves in the eye over approximately three to four months. If further treatment is needed, a new implant can be inserted.

Ozurdex is inserted into the vitreous cavity of the eye (the gel-like interior of the eye) by a specialist ophthalmologist using a specially designed applicator. It is done as an outpatient procedure under local anaesthesia.

You will not administer this implant yourself. The procedure takes only a few minutes.

After insertion, you may need antibiotic eye drops to reduce the risk of infection. Your doctor will advise how long to use these.

Ozurdex is given in a clinical setting. Contact your eye specialist if you need to reschedule a procedure.

An overdose is not applicable for this implant. Contact your eye specialist if you have concerns after the procedure.

Storage is managed by the treating clinic. The implant must be stored below 25°C and protected from freezing.

Side effects are related to the corticosteroid's effects inside the eye.

Very common side effects:

• Raised pressure inside the eye (intraocular hypertension): one of the most important side effects. Eye pressure is monitored after the procedure
• Cataract formation or progression: dexamethasone accelerates cataract development with repeated use

Common side effects:

• Eye pain after the procedure
• Floaters
• Conjunctival haemorrhage (redness of the eye)
  
  

Serious but less common side effects:

• Endophthalmitis (infection inside the eye): increasing pain, redness, or worsening vision after the procedure requires urgent attention
• Retinal detachment: sudden flashes or a curtain across your vision requires urgent care

Your eye specialist will monitor eye pressure and vision after each implant.

Because Ozurdex is placed directly into the eye and very little dexamethasone enters the bloodstream, systemic drug interactions are unlikely. However, tell your eye doctor about all medicines you take, including other eye drops.

Will the implant need to be removed?

No. Ozurdex is biodegradable and gradually dissolves in the eye over three to four months. There is no need for a removal procedure. Once the dexamethasone is released and the implant has dissolved, you and your specialist will discuss whether a repeat implant is needed.

Can I have Ozurdex if I have glaucoma?

Glaucoma (a condition where high eye pressure damages the optic nerve) is a relative contraindication to Ozurdex because the implant raises intraocular pressure. Your eye specialist will assess your specific situation. If Ozurdex is used, very close monitoring of eye pressure is required and additional glaucoma treatment may be needed.

Ace provides accurate and independent information medically reviewed on prescription medications. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.