SYNAREL® is a gonadotropin-releasing hormone (GnRH) agonist used in Assisted Reproductive Technology (ART) treatments, such as in vitro fertilisation (IVF). It is prescribed to suppress the natural release of luteinising hormone (LH) and follicle-stimulating hormone (FSH), creating a controlled environment for ovarian stimulation.

SYNAREL® is also used to manage endometriosis by reducing estrogen production and alleviating symptoms.

For IVF, the typical dosage is one spray (200 micrograms) into each nostril twice daily, starting on specific days of the menstrual cycle as directed by your fertility specialist.

For endometriosis, the dosage is usually one spray into one nostril in the morning and one spray into the other nostril in the evening.

Your doctor will provide detailed instructions tailored to your treatment plan.

If you forget to use SYNAREL®, administer the missed dose as soon as you remember, unless it is close to the time of your next scheduled dose. In that case, skip the missed dose and continue with your regular schedule.

Do not use a double dose to make up for the missed one.

Contact your doctor if you are unsure.

In case of an overdose, symptoms may include nausea, dizziness, or nasal irritation.

Contact the Poisons Information Centre (Australia: 13 11 26) or your doctor for guidance.

Store SYNAREL® below 25°C in an upright position, away from light and moisture. Do not freeze the medication.

Keep it out of reach of children and discard any unused spray after 30 days if using two sprays daily, or after 15 days if using four sprays daily.

Common side effects include nasal irritation, headaches, hot flushes, and mood changes. Some women may experience vaginal dryness, decreased libido, or mild bone density loss.

Rare but serious side effects include allergic reactions, such as difficulty breathing or swelling of the face or throat.

Contact your doctor immediately if you experience severe symptoms.

SYNAREL® may interact with other hormonal medications or nasal decongestants.

Inform your doctor about all medications, supplements, or herbal products you are taking to avoid potential interactions.

If you need to use a nasal decongestant, wait at least 30 minutes after using SYNAREL®.

How does SYNAREL® work in fertility treatments? SYNAREL® suppresses the natural release of LH and FSH, allowing for better control of ovarian stimulation during ART procedures. This ensures optimal timing for egg retrieval.

Can I administer SYNAREL® myself? Yes, SYNAREL® is designed for self-administration. Your doctor or nurse will provide instructions on how to use the nasal spray correctly. Ensure the spray is primed before the first use.

What should I do if I experience side effects? Mild side effects, such as nasal irritation or headaches, are common and usually temporary. If you experience severe symptoms, such as difficulty breathing or swelling, contact your doctor immediately. Your healthcare team is here to support you.

Can SYNAREL® be used during pregnancy? No, SYNAREL® must not be used during pregnancy. If you suspect you may be pregnant while using SYNAREL®, contact your doctor immediately.

How should I store SYNAREL®? Store SYNAREL® below 25°C in an upright position, away from light and moisture. Discard any unused spray after the recommended period.

Ace provides accurate and independent information medically reviewed on prescription medications. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.